BowTied Bull
No non-sense writing style covering: 1) Crypto, 2) Tech Stocks, 3) WiFi money and 4) Real Estate. Written by anon Ex-Wall St and Tech Individuals. SPONSOR FREE.
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Markets, macro, personal finance and biotech investing from the BowTied jungle. 6 publications, newest posts first.
No non-sense writing style covering: 1) Crypto, 2) Tech Stocks, 3) WiFi money and 4) Real Estate. Written by anon Ex-Wall St and Tech Individuals. SPONSOR FREE.
Sharing my successes and failures in various finance, real estate and corporate life. What I did right (and wrong) in those various areas and what I learned in…
Daily Biotech Public & Private Market Updates, Company Building, Financing, Exit Strategies, and Emerging Science Trends
Financial Advice with some rants on Fitness, Family, and general Fixing of Bad Advice You will learn what to do to get in the top 10% of health and wealth
Models but also whatever I want
Psychology, Persuasion, and Markets.


Hello Avatar! Welcome to the BowtiedBiotech podcast, where science meets business! If you're fascinated by breakthrough biotech, bold innovations, and the business behind the science, you're in the right place. Each week, we dive…


Hello Avatar! Another week of biotech news is in the history books. We are proud to bring you the latest edition of our weekly biotech news fix. The content is designed to be consumed as a quick scroll to bring readers up to…


Welcome back & Happy Halloween to those who celebrate (Apparently in 2026 you need that qualifier on Halloween now too or something). The F’er family does indeed go out for Halloween and despite my continued prodding the lil…




Welcome Avatar! In a rare case we’ll go ahead and chime in on this recent event. Like any of these big scary headlines it usually ends up being (relatively) predictable. In addition to that, we did get some quick earnings after…


Hello Avatar! Welcome to another week of biotech analysis. Today’s commentary, as always on Thursday, focuses on the general market update. This week confirmed the playbook. Biotech can rally and capital can return quickly, but…


Welcome Avatar! Your favorite sewer-dwelling rodent returns ( CryptoMouse ), this time to talk the META Muse rule of three, Zuck AI edition. Caveat: Muse is a Meta brand, that covers both products and the AI models that power…




Welcome Avatar! Another day has gone by and the world has not ended. If you have looked at social media, the recent doom loop has suggested both the UK and Japan should prepare for days/weeks/months of mass cyber disruption.…


Summit Therapeutics ($SMMT) is a catalyst-driven setup centered on the November 14, 2026 FDA PDUFA for ivonescimab plus platinum-doublet chemotherapy in patients with advanced or metastatic EGFR-mutated non-small cell lung cancer…


Welcome Avatar! Pretty wild weekend. We’ve got Elon calling for a slow down in the AI infrastructure build out. Big fears all over the timeline related to an energy related hack. And. A wave of layoffs at various large cap…


Hello Avatar! Welcome back for another week of biotech analysis. Today is Sunday, which means this is our Building Biotech newsletter that is focused on discussing biopharma strategy topics. This week, we’re diving into the…


Hello Avatar! Welcome to the BowtiedBiotech podcast, where science meets business! If you're fascinated by breakthrough biotech, bold innovations, and the business behind the science, you're in the right place. Each week, we dive…


Welcome back. The end of the year is coming in hot. You know how it goes, Halloween → Thanksgiving → Christmas → New Years. And we also have the added benefit of nearly every member in the extended family having a Q4 birthday.…


It is a common line of reasoning to cite the real yield-inflation breakeven decomposition and conclude that the move in bonds in the U.S. lately is showing rising growth expectations and not pricing any inflation. Read more


Hello Avatar! Another week of biotech news is in the history books. We are proud to bring you the latest edition of our weekly biotech news fix. The content is designed to be consumed as a quick scroll to bring readers up to…


Welcome Avatar! As a quick preview for part of Sunday’s post, one thing we’re noticing is that old P/E and ETF analysis is no longer relevant in 2026. We’ve all watched as the same charts pop up. “20 companies are driving all the…


Check out the group chat for more detail here. Link below. Read more


Hello Avatar! Welcome to another week of biotech analysis. Today’s commentary, as always on Thursday, focuses on the general market update. This week confirmed the playbook. Biotech can rally and capital can return quickly, but…


Welcome Avatar! Considering all the tech news we thought it would be a good time to quantify how some of our mega themes are playing out. The mega themes are still the same: 1) degeneracy, 2) loneliness, 3) K-shape Economy - rich…


Hello Avatar! Welcome to the BowtiedBiotech podcast, where science meets business! If you're fascinated by breakthrough biotech, bold innovations, and the business behind the science, you're in the right place. Each week, we dive…




Spyre Therapeutics ($SYRE) is a catalyst-driven setup centered on the expected Q4 2026 Phase 2 SKYWAY readouts for SPY072 in psoriatic arthritis (PsA) and axial spondyloarthritis (axSpA). This is a clinical data catalyst testing…


Welcome Avatar! Several Jungle natives have created 7-8 figure brands at this point. With that in mind we think it’s a good time to give you a clean explainer for why Entrepreneurs end up over investing. This is the inverted…


I find myself frequently sharing this incredible prediction from March 24 (paywall has been removed on the paid article) lately so I thought it would be a good time to revisit the dynamic. Obviously much has happened since March…


Welcome Avatar! It looks like we’re getting the hiccup for AI companies. In the end, we all know they will print money or drop interest rates to near zero. No other way around it. In the interim, good time to look at what is most…


(I have multiple completed drafts from many months ago when this newsletter was figuring out its niche. My most recent article on austerity and inflation is unusually long so I’m taking the opportunity this week to share this…


Hello Avatar! Welcome back for another week of biotech analysis. Today is Sunday, which means this is our Building Biotech newsletter that is focused on discussing biopharma strategy topics. This week, we’re diving into the…


Welcome back. Last week we went through all the silly arguments being made for why paying off a historically cheap mortgage is ‘better’ than keeping the mortgage plus buying significantly higher yielding US Treasury. Here is the…


Hello Avatar! Welcome to the BowtiedBiotech podcast, where science meets business! If you're fascinated by breakthrough biotech, bold innovations, and the business behind the science, you're in the right place. Each week, we dive…


Welcome Avatar! Well it is officially October 16 so its time to actually care about crypto and high-tech. We’re seeing higher oil prices, bad inflation prints, likely some layoffs in the near-term and back to the money printer…


Welcome Avatar! Pretty wild week and it looks like the Q4 pull down may happen we’re going to do a mini overview, reiterate our own strategy and write out where we think the opportunity is. In addition, since we’ll have purchases…


Welcome Avatar! This is a bonus guest post (standard paid post on Wednesday Night still coming) since we know we’re at tax deadline. For those that need an update we have a CPA here who does nothing buy crypto taxes. Best to get…




Welcome Avatar! If you’re a good operator, you’re not worried about AI. That has remained true the entire year. In fact, entry level people abusing AI are only making their lives worse. If the higher up recognizes that the…


The origin of this article is a subscriber question about a throwaway Trump comment about paying off the debt recently (October 2). It’s a good question. People generally say what they mean; what they are actually thinking. 1 Not…


Thanks to BowTiedBull, my twitter feed is about 50% tweets about mortgage payoff - the other 50% is a mix of social security arguing and the standard nonsense that you have no idea why its popping up. If you have been a reader…


Trump has revoked more energy sanctions on Russia with the excuse of the ongoing diesel crisis. “Never let a crisis go to waste,” as they say. This is something I mentioned in March: how the geopolitical progressions would likely…


“Two is one, and one is none” This is the common saying used by faux Boomer prep-ers when they justify all the stuff they own. If you have ever been doing some handy work and realize you are missing some niche and expensive tool…


I’m going to start doing a monthly asset summary (thanks to for the excellent suggestion). This will be nice because: My articles are generally concept-focused and finding my overall market views by reading through all my notes…


There aren’t major investment implications from this update but I’ve gotten asked about this by paid subs and it appears other friends of Notes From Underwater are boosting the claim so I thought it would be worth sending a short…


The Bell Curve. A lot of you may only be familiar with the bell curve from the memes. However, it is a concept that springs up again and again in the actual world. There are millions of these memes out there for every topic…


Welcome back. This week we are combining a reader request for some thoughts about crypto with a vaguely crypto adjacent topic of hacks/scams and accounts being drained. The example of the hack in this post is a new one that I…


Welcome Back Dear Reader. Do you consider yourself smart? Do you feel like you work hard? Yet, do you still feel like you are being left behind? Would you spend $204 for a $1 bill? You are not alone. In fact, a lot of smart and…


Welcome back. Let’s start this week’s post with some good news. The Michael Dell philanthropy money for the Trump Accounts hit the lil F’ers accounts a few days ago. As discussed in the post about Trump accounts, there was some…


Welcome back. Another week in the rearview and we are rolling into the last month of Q3. Every quarter there is a handful of topics that would be a stretch to make their own post, but fit perfectly as smaller, condensed sections.…


Welcome Back. This week’s post is brought to you by one of the misguided budgetpoor accounts on twitter and a rehash (and probably scheduled to go off once every month) tweet: There are just so many directions you can go on…


Around 2008, when I was in the pest control business, the company I worked for serviced a large hotel chain. When we did pest control work for a large commercial brand, we would call those “National Accounts”. They were IMPORTANT…