By BowTiedLoon on Substack · Hundreds of subscribers · 12 free and 0 paid among the latest 12.
Health suggestions and lab interpretation (not medical advice) for people who want to be better than "normal"
As we’ve previously discussed , there are essential 3 main horseman of cardiovascular disease: Lipids Endothelial health Inflammation Measurement of inflammatory burden has limitations, since the most common labs to look at this…
Lipoprotein(a), or Lp(a), is one of the ApoB containing lipoproteins that carries a higher than expected risk for development of cardiovascular disease than its closely related LDL particle. If you don’t know what Lp(a) is, you…
As discussed in the last article, Overview of POMC and downstream effects and regulation , proopiomelanocortin (POMC) is an important precursor peptide that plays a crucial role in various physiological processes, including the…
Proopiomelanocortin (POMC) is a precursor polypeptide (241 amino acids) that is cleaved into several other active peptides in the body, with various physiological effects, depending on where the peptide is processed. POMC is…
Dihydrotestosterone (DHT) is a potent androgen hormone, synthesized from testosterone by the enzyme 5-alpha reductase. As I said in the subtitle, DHT is what makes men feel, look, and act like men. The effects of DHT in men: Read…
Homocysteine is a sulfur-containing amino acid derived from the demethylation of methionine, an essential amino acid. It's not obtained from the diet but rather produced endogenously. Homocysteine plays roles in cellular…
Clomiphene, which is commonly known by its brand name Clomid, is a selective estrogen receptor modulator (SERM) that is made of a mix of two isomers — enclomiphene and zuclomiphene. The FDA label for clomiphene is for treatment…
The terms GLP-1 and leptin have quickly become the hottest topics in weight loss and weight management, and big pharma would have you believe the only way to stimulate GLP-1 receptors is by taking one of their GLP-1 agonists (eg…
Over time, I’ve gotten occasional questions about the use of oral isotretinoin for acne. Isotretinoin is often better known by the brand name Accutane, or also available as Claravis in the US, or Roaccutane in Europe/other parts…
Let’s start the year off with a Q&A, since I’ve never done one before. I’ll open this first one up to both paid and free subscribers, but will close comments in a few days. BowTiedLoon’s Newsletter is a reader-supported…
This post is written with the assumption that you’ve already decided to start on testosterone replacement therapy. I have already covered what I think the optimal way to start TRT is here: What starting TRT looks like . Summary:…
Tadalafil is a medication that works as a phosphodiesterase type 5 (PDE5) inhibitor that is FDA approved for erectile dysfunction (ED) and benign prostatic hyperplasia (BPH). It first became available in 2003 under the brand name…